At BrainVisionCenter, one of our primary goals is to empower young researchers and support their scientific careers. As part of this commitment, we are proud to announce that another member of our team has successfully earned a PhD degree.
The title of Miklós Madarász’s doctoral thesis is:
“The applicability of chronically implantable and transparent microECoG devices for the simultaneous measurement of spontaneous calcium and electrophysiological activity in awake mice.”
During the research, the applicability of transparent, implantable ECoG devices based on Parylene HT/ITO and Thiol-ene/acrylate/SIROF was investigated through both in vitro and in vivo experiments in awake mice using two-photon imaging techniques.
As a central objective of the study, the devices were implanted onto the cortical and hippocampal surfaces of mice, enabling the long-term validation of simultaneous electrocorticography (ECoG) and two-photon calcium imaging measurements. The findings confirmed that all tested devices are suitable for combined ECoG and two-photon calcium imaging studies in awake mice.
The devices demonstrated excellent optical transparency, while their electrochemical properties enabled the recording of high-quality signals with minimal electrode loss even several months after implantation.
Overall, the dissertation concluded that the presented transparent, implantable microECoG devices are highly promising tools for chronic, simultaneous electrocorticography and two-photon calcium imaging studies in awake mice, as well as for the parallel electrophysiological and optical mapping of cell-level activity in neural networks.
These results represent another important milestone in the advancement of our Institute’s neurological research activities.
We congratulate our colleague on this outstanding scientific achievement!
