Project ID No: 2025-3.1.1-ED-2025-0002
Project title:
Development of a multimodal neuroscience platform for a mouse model: targeted neuronal labeling, cell type–specific learning mechanisms, realistic MoculusVR environment, and freely moving two-photon imaging integrated into complex behavioral paradigms.
Short summary of the project:
The aim of the project is to develop new tools that will help us understand in greater detail how the brain works during learning, perception, and behavior. Part of this involves further developing a special virtual reality (VR) system called Moculus, which we designed specifically for mice. This system allows animals to move in a true three-dimensional (3D) environment, which is essential for them to learn and navigate naturally. The goal is for this system to more accurately mimic the natural vision of mice, while becoming an easy-to-use, multi-instance device that can be used by international research groups.
In parallel, another line of research is investigating the neural basis of learning. We are paying particular attention to a special type of cell, VIP interneurons, which play a role in how sensory information is transformed in the brain when, for example, the rules of reward change. For such studies, we perform targeted genetic modification using special viral vectors (AAVs), which allow us to make individual nerve cells visible or controllable by light.
The third pillar of the project is the development of a new robotic arm optical system that allows us to perform two-photon imaging on mice even when they are moving freely. This is a breakthrough because it allows us to observe brain function under much more natural conditions. In addition to developing the system, we also aim to launch a domestic scientific collaboration to help introduce the new technology and ensure the physiological validity of the measurements.
Project implementation period: 2025.07.01 – 2025.10.31
Project budget: 100.000.000 Ft
Project aid intensity: 100%
Project location:
1094 Budapest, Liliom u. 43.
1094 Budapest, Tűzoltó u. 59.
7673 Kővágószőlős 524/1.
