Technology Overview:

Cre-recombinase protein can be used for turning genes on/off, and lineage tracing. Fusing it with estrogen receptor (ER) prevents nuclear localization of the Cre-ER protein. Tamoxifen can be used for the activation of the Cre-ER system, thus allowing for a temporal control of reporter activation. ONB caged tamoxifen allows a precise spatio-temporal control of the release in response to a light-trigger. The caged compound exists as trifluoroacetic acid salted form ensuring good solubility, stability, and low hygroscopicity.

 

Features

• Name: (Z)-N-(4-(2-((2-aminoethyl)amino)-2-oxoethoxy)-5-methoxy-2-nitrobenzyl)-2-(4-(1,2-diphenylbut-1-en-1-yl)phenoxy)-N,N-dimethylethan-1-aminium trifluoroacetate
• Molecular formula: C₄₀H₄₅F₃N₄O₈
• MW: 766.82 Da
• Standard packaging size: 10 mg

 

Benefits

• Rapidly and efficiently releases Tamoxifen, by the effect of UV irradiation.
• Exists as trifluoroacetic acid salted form, ensuring good solubility, stability and low hygroscopicity of the product.

 

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References

Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification

Matthew A. Inlay et.al.  Chem. Commun. (2013)